Nu-Joint
Research physician Ed Petrus, M.D. discovered the formulation for Nu-Joint while seeking help for his arthritic knees. He found that relief with glucosamine was unpredictable and that chondroitin upset his stomach.
Studies showed that glucosamine assists in the production of new articular cartilage and inhibits cartilage-destroying enzymes.1 A three-year study showed that subjects who took glucosamine had reduced symptoms and no loss of cartilage.2
Articular cartilage covers the ends of bones and acts as the body’s shock absorbers by cushioning the bones from weight bearing stress. As our body ages the ability to repair and produce cartilage declines.
A discovery leads to a patent
Research disclosed that nitric oxide, a naturally produced gas in the body, prevents glucosamine from making new cartilage3 and breaks down cartilage.4 Increased levels of nitric oxide in the joint fluid of both osteoarthritis and rheumatoid arthritis patients was noted to prevent chondrocytes, the cartilage producing cells, from making and repairing articular cartilage.5 Eliminating nitric oxide in the joint fluid was essential to producing and repairing joint cartilage. Dr. Petrus experimented with different mixtures of dietary ingredients and found a formulation that provided him relief from his arthritic symptoms and obtained a patent for his discovery.6
Max's story
During this time his 11 year old Weimaraner Max was noted to have difficulty lifting his leg to pee and had arthritic tenderness of the hips. Capsules of what would later become Nu-Joint were put into Max’s food and after ten days he was able to lift his leg without pain.
A balanced formula
People who have found glucosamine products unsatisfactory in the past may benefit from the balanced Nu-Joint formula. Nobel Laboratories comprehensive formulation Nu-Joint provides the nutrients known to be effective in maintaining mobile joint function of the knees, hands, fingers, wrists, elbows, shoulders, neck, hips, feet and back.
Now available
Nu-Joint is available in 90 & 180 capsules and also in a 1 oz. & 2 oz. penetrating gel to be applied to the symptomatic joint. The Nu-Joint capsules are taken daily and the Nu-Joint penetrating gel is applied where needed. It is recommended that they be used together.
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- Margolis S, Flynn JA, Arthritis, The Johns Hopkins White Papers, Baltimore, 2001, pg. 5.
- Reginster JY, et al, Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled clinical trial, The Lancet 2001:357:251-256.
- Johnson K, et al, Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization, Arthritis & Rheumatism 2000; 43(7):1560-1570.
- Arthritis Today March-April 2002, Vol. 16, No. 2.
- Henrotin YE, et al, Nitric oxide downregulates cytokines, J of Rheumatology 1998; 25(8):1595-1601.
- U.S. Patent No. 6,346,519 and patents pending.